[1] The administrative centre of Tolikara Regency is the town of Karubaga.

The table also includes the locations of the district administrative centres, the number of administrative villages in each district (totaling 541 rural kampung and 4 urban kelurahan), and its post code.

Since 2010, the former districts of Dorman (which had 171 inhabitants in 2010) and Sbey (which had 111 inhabitants in 2010) have ceased to exist, while thirteen new districts have been created, which are: Aweku, Bogonuk, Li Anogomma, Biuk, Anawi, Wugi, Wenam, Kai, Tagime, Danime, Yuko, Telenggeme and Gika.

The VI Asian-Pacific Astronomy Olympiad took place in Tolikara in November–December 2010.

Karubaga has a cool tropical rainforest climate (Af) with heavy rainfall year-round.