Toloxatone (Humoryl) is an antidepressant launched in 1984 in France by Sanofi Aventis for the treatment of depression.

[1] It acts as a selective reversible inhibitor of MAO-A (RIMA).

[2] The reaction between glycidol (1) and m-toluidine (2) gives 3-m-toluidinopropane-1,2-diol (3).

Treatment with diethyl carbonate (4) in the presence of sodium methoxide leads to an intermolecular cycloaddition to give tomoxatone.

[3][4][5] This drug article relating to the nervous system is a stub.