[2] On 15 August 1566, Tommaso Orsini was appointed during the papacy of Pope Gregory XIII as Bishop of Strongoli.
[2][3] On 28 August 1566, he was consecrated bishop by Clemente d'Olera, Cardinal-Priest of Santa Maria in Ara Coeli, with Antonmaria Salviati, Bishop Emeritus of Saint-Papoul, and Giulio Antonio Santorio, Archbishop of Santa Severina, serving as co-consecrators.
[3] On 23 January 1568, he was appointed Bishop of Foligno by Pope Gregory XIII.
[1][3] He served as Bishop of Foligno until his death on 25 January 1576.
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