The game was televised in the United States by Fox and began shortly after 11:40am local time (4:40pm EST) following Pole Qualifying for 2008 Daytona 500.

NFC running back Adrian Peterson rushed 16 times for 129 yards and was named the game's MVP, winning a Cadillac CTS in recognition of his efforts.

The Dallas Cowboys had a record thirteen players named to the Pro Bowl roster, while five teams, including all four members of the NFC South, had no players initially named (Jeff Garcia of the Tampa Bay Buccaneers was later chosen as a replacement quarterback for Brett Favre.)

On February 4, 2008, Brady, Patriots receiver Randy Moss, Chargers tight end Antonio Gates, and Chargers defensive lineman Jamal Williams decided to pull out of the 2008 Pro Bowl.

Notes: The halftime show featured a performance by the band Lifehouse, who played their songs "Hanging by a Moment" and "First Time".