Greenblatt-Janollari started producing shows in the 1998–1999 season with 3 comedy series for ABC and CBS.

Early output by the individual units, or "pods", were FTSP's Son of the Beach for FX, The Hughleys by G-JS and Regency had Malcolm in the Middle.

Daniella Welteke was tapped up to head the division, which was eventually folded into Fox World.

The company produced international versions of its reality television programs such as Joe Millionaire and Temptation Island.

On March 5, 2001, SBS inked a deal/joint venture with Fox World to launch a northern European-based production company.

[10] On November 22, 2004, Hayley Babcock was named senior vice president of production at the Fox World studio, while Daniella Welteke would remain as head of the division.

[11] Fox Lab was a low-profile production sub-division of 20th Television, originally formed in 1986 as Fox Television Stations Productions (or FTSP) and was responsible for the development of A Current Affair, Cops and America's Most Wanted.

It was rebranded to the current moniker in 1995, although the FTSP label was continued to be used on several older shows until Fox's cancellation of Cops in 2013.

[6] After originally being passed over for programming the new network, MyNetworkTV, Fox 21 was in consideration along with Twentieth Television and independent producers as of December 2006 in a potential reprogramming from telenovela to low-cost reality and game shows.

[6] In early 2015, Mythology Entertainment signed a first look deal with the company and its sister studio 20th Century Fox Television while announcing the head of its TV division.

This situation came as a result of FTVS's president David Madden being promoted to Fox Broadcasting Company and the fact that both units were focusing on the same market, cable television.

[6] In January 2020, Fox 21 reached a first-look deal with Marta Kauffman's studio Okay Goodnight, beginning with an adaptation of the 2019 novel The Dreamers.