Toughkenamon is a census-designated place (CDP) in New Garden Township, Chester County, Pennsylvania, United States.

Thomas and Mary Rowland settled in the valley, near the present village of Toughkenamon, in 1706, being perhaps the first settlers who purchased lands in New Garden Township.

For example, the farmers dug trenches around their crops, and filled them with water, to prevent reoccurrence of the conflagration that occurred when local Lenapes started a burn.

The fact that the original Toughkenamon settlers maintained water-filled trenches is evidence that they had dialogue and an understanding of the importance of the burn.

But later settlers no longer interacted with the departed tribe, so falsely assumed the burns had been solely aimed at destroying their ancestors' crops, adding to mistrust of remaining Native-American families in nearby counties.

It was an early industrial center due to its strategic location on the old Baltimore Pike between Philadelphia and Washington, D.C., easy access to raw materials such as wood, water and ore.

Even today, businesses critical to national wholesale distribution of perishable foods are located in and near Toughkenamon.

Toughkenamon is located east of Pennsylvania Route 41 in Avondale on the old Baltimore Pike, a few miles west-southwest of Kennett Square.