Towada-Minami Station was opened on July 4, 1920, as Kemanai Station (毛馬内駅) on the privately owned Akita Railways, serving the village of Nishikigi, Akita.

The line was nationalized on June 1, 1934, becoming part of the Japanese Government Railways (JGR) system.

The JGR became the Japan National Railways (JNR) after World War II.

The station was absorbed into the JR East network upon the privatization of the JNR on April 1, 1987.

[1] Media related to Towada-Minami Station at Wikimedia Commons