Transcriptome instability is a genome-wide, pre-mRNA splicing-related characteristic of certain cancers.
In general, pre-mRNA splicing is dysregulated in a high proportion of cancerous cells.
[1][2][3] For certain types of cancer, like in colorectal and prostate, the number of splicing errors per cancer has been shown to vary greatly between individual cancers, a phenomenon referred to as transcriptome instability.
[4][5] Transcriptome instability correlates significantly with reduced expression level of splicing factor genes.
Mutation of DNMT3A contributes to development of hematologic malignancies, and DNMT3A-mutated cell lines exhibit transcriptome instability as compared to their isogenic wildtype counterparts.