In the field of molecular biology, transrepression is a process whereby one protein represses (i.e., inhibits) the activity of a second protein through a protein-protein interaction.
Since this repression occurs between two different protein molecules (intermolecular), it is referred to as a trans-acting process.
Hence the net result of transrepression is down regulation of gene transcription.
[1][2] In addition to transactivation, transrepression is an important pathway for the anti-inflammatory effects of glucocorticoids.
[3][4] Other nuclear receptors such as LXR and PPAR have been demonstrated to also have the ability to transrepress the activity of other proteins.