[3] The album's lead single, "Sweetest Pie" with English singer Dua Lipa, peaked at number 15 on the US Billboard Hot 100 and has been certified platinum by the Recording Industry Association of America (RIAA).

In 2020 Megan Thee Stallion filed suit against her record label 1501 Certified Entertainment to renegotiate her contract, after her management company Roc Nation found it "iffy".

[9] Megan defined the album title as referring to a chemical released in the brain when forced to deal with "painful emotions caused by traumatic events and experiences.

[10][11] After the low promotion of Traumazine by the label, Thee Stallion has started a second lawsuit, accusing the company of contributing to the album's poor sales and marketing.

Tell it my way, tell it from me.The album featured several collaborations from Dua Lipa, Future, and Key Glock, and additional guest appearances from Latto, Pooh Shiesty, Rico Nasty, Jhené Aiko, Lucky Daye, Sauce Walka, Lil' Keke, and Big Pokey.

Mendez additionally noted the "dark and ominous" production tone, with lyrical references to the difficult rise for an African American woman in the music industry and the legal battle to dissolve her 1501 Certified record contract.

[15] NPR editor Sidney Madden defined the album as a "huge artistic step" because "tracks are offset with deep contemplations about the trauma she's experienced in her life so far and, more pointedly, the double standards in society that black women carry with them when they're objectified".

[14] In a more reserved review for AllMusic, Fred Thomas described the album as, "solid but inconsistent, with one foot in formula-tested mainstream rap and the other in a more confessional, emotionally bare territory that's new for Megan Thee Stallion.

Despite its occasional unevenness, the album is exciting in both its moments of audience-tested hitmaking and when Megan cracks the veneer of her invincible persona to share feelings that are difficult, messy, and real.