[14] He finished his rookie season with one sack, 44 total tackles, seven passes defensed, and one forced fumble in 11 games and starts.

[15] McDuffie helped the Chiefs reach Super Bowl LVII where he recorded five tackles in the 38–35 victory over the Philadelphia Eagles.

[16] Before the start of the 2023 season, McDuffie changed his jersey number from 21 to 22 to honor his brother Tyler, who died in 2015.

[17] McDuffie finished his second season with three sacks, 80 total tackles, seven passes defensed, and five forced fumbles.

The Chiefs reached Super Bowl LVIII where they defeated the San Francisco 49ers 25–22 giving McDuffie his second straight championship.