[1] According to David Albright, South Africa's nuclear weapons used TATB to increase their safety.

TATB has been found to remain stable at temperatures at least as high as 250 °C for prolonged periods of time.

TATB is produced by nitration of 1,3,5-trichlorobenzene to 1,3,5-trichloro-2,4,6-trinitrobenzene, then the chlorine atoms are substituted with amine groups using ammonolysis.

However, it is likely that the production of TATB will be switched over to a process involving the nitration and transamination of phloroglucinol, since this process is milder, cheaper, and reduces the amount of ammonium chloride salt produced in waste effluents (greener)[citation needed].

When picramide, which is easily produced from Explosive D, is reacted with TMHI it is aminated to TATB.