Its range within the eastern United States is south of Pennsylvania, in the midwest north to Ohio and Missouri and in the southwest to Arizona.

[5] Triatoma sanguisuga is a known vector for Trypanosoma cruzi, a zooflagellate protozoan that inhabits the blood and causes Chagas disease.

[6] Like other species of kissing bugs, Triatoma sanguisuga is known to bite humans in the face, usually around the mouth or eyes, and feed off the blood.

There have been a total of seven cases of human infections from any species of Triatoma reported in Texas, California, Tennessee, and Louisiana.

[5][8] Triatoma sanguisuga can be controlled in the home by using screens on all windows and doors, and sealing all cracks in walls and ceilings.