Tribeca Grill is a New American restaurant at 375 Greenwich Street (at Franklin Street) in Tribeca, Manhattan, New York City, co-owned by Robert De Niro and Drew Nieporent.

Celebrity investors include Bill Murray, Sean Penn, Christopher Walken, Ed Harris, and Lou Diamond Phillips, among others.

Restaurateur Drew Nieporent had opened a restaurant in Tribeca in 1985 called Montrachet, naming it after the Burgundy wine region.

The actor Robert De Niro, who was a regular customer at Montrachet, is quoted as saying "I always thought of having a restaurant — a place where people could meet and talk.

Large paintings on the wall are original paintings by Robert De Niro Sr.[8] A 2000 interior renovation included the addition of large lighting fixtures by the architect David Rockwell.