Trifluridine (also called trifluorothymidine; abbreviation TFT or FTD[1]) is an anti-herpesvirus antiviral drug, used primarily as prescription eyedrops.

[3] A Cochrane Systematic Review showed that trifluridine and aciclovir were a more effective treatment than idoxuridine or vidarabine,[4] significantly increasing the relative number of successfully healed eyes in one to two weeks.

[4] Common side effects of trifluridine eye drops include transient burning, stinging, local irritation, and edema of the eyelids.

At least 57% of trifluridine are absorbed from the gut, and highest blood plasma concentrations are reached after two hours in cancer patients.

[5] Tipiracil causes Cmax (highest blood plasma concentrations) of trifluridine to increase 22-fold, and its area under the curve 37-fold, by inhibiting thymidine phosphorylase.