The company was founded in February 1991 by Graeme Devine and Rob Landeros, who had been fired from Virgin Games after pitching their idea for The 7th Guest.

Graeme Devine and Rob Landeros founded Trilobyte on February 1, 1991, after being fired from Virgin Interactive.

In the game, the player must move around the map solving puzzles in a style similar to Myst.

For the time, it had state-of-the-art graphics by Rob Landeros, Robert Stein III, Gene Bodio, Alan Iglesias, MIDI music by The Fat Man, and a story by Matthew J. Costello.

Clandestiny, with gameplay similar to the previous The 7th Guest, and The 11th Hour, though using cel animated (cartoon) video rather than live action, and Uncle Henry's Playhouse, a re-packaging of a number of the puzzles and games from The 7th Guest, The 11th Hour, and Clandestiny.

By December, Trilobyte was close to reaching an agreement with Midway and Devine unsuccessfully sought funding from Paul Allen to keep the company afloat until it was finalized.

In April 2011, The 7th Guest: Infection—a stand-alone version of the popular Microscope Puzzle from the original 7th Guest—was released for iPad.

On Halloween 2013, Trilobyte launched a Kickstarter campaign for The 7th Guest 3: The Collector, which failed to meet its funding target of $435,000.

[8] Another crowdfunding campaign was started at Crowdtilt with a smaller goal of $65,000 to build the first story of the haunted mansion[9] but that too, failed, and the 7th Guest 3 was officially cancelled in June 2014.