A trophozoite (G. trope, nourishment + zoon, animal) is the activated, feeding stage in the life cycle of certain protozoa such as malaria-causing Plasmodium falciparum and those of the Giardia group.
[2] In the protozoan, Entamoeba histolytica it invades the intestinal mucosa of its host, causing dysentery, which aid in the trophozoites traveling to the liver and leading to the production of hepatic abscesses.
[4] Malaria is recorded as the most common disease in Sub-Saharan Africa, and some Asian countries with the highest number of deaths.
[6] This protozoan has several other subspecies, with some causing diseases in humans with over 91,000 death in 2021 from malaria (Plasmodium falciparium) alone, which is a 77% increase from 2020 as reported by the World Health Organization (WHO).
In the apicomplexan life cycle the trophozoite undergoes schizogony (asexual reproduction) and develops into a schizont which contains merozoites.