Trout Run is a tributary of Shamokin Creek in Northumberland County, Pennsylvania, in the United States.

It heads west-southwest for several tenths of a mile, flowing through a broad, deep valley between two ridges.

[1] Trout Run joins Shamokin Creek 20.48 miles (32.96 km) upstream of its mouth.

[3] The stream has a high level of water quality and no part of it or any of its tributaries is designated as impaired.

[5] The watershed of Trout Run is in the central part of the Shamokin Creek drainage basin.

[4][10] Trout Run was entered into the Geographic Names Information System on August 2, 1979.

[7] A channel restoration project involving 450 tons of riprap on 120 feet (37 m) of Trout Run was carried out after Hurricane Eloise.

[12] In 2015, the watershed of Trout Run was proposed as a site for the new Northumberland County Prison.

[13] A small hatchery near the mouth of the stream is maintained by a group of local sportsmen.