San Juan Bautista Tuxtepec (Nahuatl languages: Tōchtepēc, "on the hill of rabbits"), or simply referred to as Tuxtepec, is the head of the municipality by the same name and is the second most populous city of the Mexican state of Oaxaca.

Ignacio Martínez Bautista, Los Anzures, Los Ávalos, Los Ávalos, Los Cocos, Los Juanes, Los Mangales (La Estopa), Los Mangos, Los Pinos, Los Reyes (Ampliación Santa Úrsula), Macín Chico, María Domínguez, Mata de Caña, Mixtancillo (Boca de Coapa), Mundo Nuevo, Nuevo Horizonte, Ojo de Agua, Palmilla, Pantoja, Papaloapan, Paso Canoa, Paso de Armadillo, Paso Rincón, Piedra Quemada, Pillo García (Buenavista), Pio V Becerra Ballesteros, Playa del Mono, Pueblo Nuevo Ojo de Agua, Pueblo Nuevo Papaloapan, Puente del Obispo (La Joya), Rancho de San Antonio 1, Rancho de San Antonio 2, Rancho Doña Mimí, Rancho el Águila, Rancho el Sábalo, Rancho Mis Abuelos, Rancho Nuevo Jonotal, Rincón Bonito, Roberto Figueroa, Rodeo Arroyo Pepesca, Sabino Pérez, San Bartolo, San Felipe de la Peña, San Fermín, San Francisco 1, San Francisco 2, San Francisco Salsipuedes, San Isidro las Piñas, San José, San Juan Bautista de Matamoros, San Juan Bautista Tuxtepec, San Lorenzo (El Zapotal), San Martín las Caobas, San Miguel Obispo, San Pedro, San Rafael 1, San Rafael 2, San Román, San Rosendo, San Silverio el Cedral, Santa Úrsula, Santa Catarina, Santa Elena, Santa Isabel Río Obispo, Santa María Amapa, Santa María Obispo, Santa Rosa Papaloapan, Santa Silvia, Santa Teresa (Boca de Coapa), Santa Teresa Papaloapan, Santo Tomás, Sebastopol, Silvano Reyes, Silverio la Arrocera, Soledad Macín Chico, Tacoteno el Consuelo, Tecoteno el Tular, Toro Bravo, Vista Hermosa, and Zacate Colorado Together, the municipality covers an area of 933.9 km2 (360.58 sq mi) and reported a census population of 144,555, which includes many small outlying communities.

Municipal President Fernando Bautista Dávila died in 2020 during the COVID-19 pandemic in Mexico.

[4] The municipality resides in the region called La Cuenca (Spanish for “The Basin”), is located 36 feet above sea level, and occupies an area of approximately 580 square miles (1,500 km2).

The city itself is surrounded by the Papaloapan River, and lies a few kilometers south of the Cerro de Oro Dam on its tributary the Santo Domingo River.