Twin Valley South High School is a public high school in West Alexandria, Ohio.

The school colors are scarlet and gray, and the mascot is the Panthers.

Their main rival is Tri-County High School, located in Lewisburg, Ohio.

School sports include football, cross country, golf, boys and girls basketball, baseball, softball, volleyball, wrestling, co-ed track, and marching band.

This Preble County, Ohio school article is a stub.