The program's main window uses a translucent black theme similar to certain palettes used in Aperture, iPhoto and other Apple Inc. software.

[3] As of version 2.1, Twitterrific supports Growl notifications, enhanced AppleScript capabilities and can be used with other sites or services that use the Twitter API.

Version 3 changed Twitterrific into advertising supported shareware; every hour an ad is refreshed to the top of the list.

Other changes in version 3 mostly added compatibility with Mac OS X 10.5 and incorporated newer Twitter features like direct messaging.

The iOS version of Twitterrific won the 2008 Apple Design Award for Best iPhone Social Networking Application.