Its 2014 follow-up, "Or Nah" (featuring Wiz Khalifa and DJ Mustard, remixed with the Weeknd) was met with continued success and received sextuple platinum certification from the Recording Industry Association of America (RIAA).

He has released the collaborative albums MihTy (2018) with Jeremih, Cheers to the Best Memories (2021) with Dvsn, and Vultures 1 and 2 (2024) with Kanye West—Vultures 1 became his first to debut atop the Billboard 200.

[4] Along with his own career, Griffin is known his frequent guest appearances on songs by other artists; these include the Billboard Hot 100-top 40 singles "Work from Home" by Fifth Harmony, "Swalla" by Jason Derulo, "Psycho" by Post Malone, "Hot Girl Summer" by Megan Thee Stallion, "Hit Different" by SZA, and "WusYaName" by Tyler, the Creator—the latter became his first to peak the chart and received diamond certification by the RIAA.

Furthermore, Griffin has been credited with songwriting and production work for other artists, most notably on the singles "Loyal" by Chris Brown, "Post to Be" by Omarion, and "FourFiveSeconds" by Rihanna, Kanye West and Paul McCartney, among others.

[8] He has said that through his father's involvement in Lakeside, he met singers like Earth, Wind & Fire and Prince as a child, which led to his love and interest for soul music.

[12] The duo also made guest appearances on studio albums by other artists such as Sa-Ra Creative Partners and Black Milk.

[26][27] The single became highly popular, peaking at number 29 on the US Billboard Hot 100 and eventually being certified platinum by the Recording Industry Association of America (RIAA).

[28] On January 7, 2014, Griffin released his second single for his debut EP, titled "Or Nah" (featuring Wiz Khalifa and DJ Mustard).

The EP features guest appearances from Casey Veggies, Wiz Khalifa, Twista, Jay Rock, Trey Songz, French Montana, Travis Scott, and Fredo Santana, while the production was primarily handled by Griffin himself, along with DJ Mustard,[33][34] Cardo, and Young Chop, among others.

[38] In May 2014, Griffin told The Fader, that he would release a mixtape, titled Sign Language, sometime during the next few months, which would then be followed by Free TC.

[39] In August 2014, Griffin revealed that Jeremih, Wiz Khalifa, YG, Yo Gotti, and Jay 305, will be appearing on Sign Language.

[40] On August 24, 2014, which happens to be the same day he released his mixtape Sign Language, Griffin told HotNewHipHop, that he has worked with Rihanna on a track from her then-upcoming album; the result was him having a songwriting credit on her 2015 hit single "FourFiveSeconds".

On May 26, 2015, Griffin released the first single from Free TC, titled "Only Right", which features TeeCee4800, Joe Moses, and YG, and was produced by DJ Mustard.

On June 26, 2015, he released the album's second single, titled "Blasé" (featuring Future and Rae Sremmurd), which would go on to receive platinum certification from the RIAA.

[45] In February 2016, Griffin guest featured on Fifth Harmony's hit single "Work from Home", which peaked at number 4 on the Billboard Hot 100.

[46][47] In June 2016, Griffin, Lil Wayne, Wiz Khalifa, Imagine Dragons, Logic, and X Ambassadors released the collaboration single "Sucker for Pain" for the motion picture soundtrack for Suicide Squad.

The duo's eponymous album was released to mild critical and commercial reception, and featured guest appearances from French Montana, Chris Brown, and Wiz Khalifa, and executive production from Hitmaka.

[55] On July 1, 2020, Griffin released "Ego Death" (featuring Kanye West, FKA Twigs, and Skrillex) as the official lead single to his third studio album.

[56] On July 3, 2020, Griffin announced to Big Boy that his third studio album is called Dream House and would be released "sooner than you think".

[58] On October 14, Griffin revealed that he changed the album's title to Featuring Ty Dolla Sign, a reference to his work on other artists' projects and songs since his last release.

The album features artists including Kid Cudi, Post Malone, Kanye West, Anderson .Paak, Quavo, Lil Durk, Nicki Minaj, Big Sean, Jhené Aiko, Kehlani, Future, Musiq Soulchild, FKA Twigs, and Skrillex.

[60] Griffin was also featured on the song "Safety Net" by Ariana Grande for her sixth studio album, Positions on October 30, 2020.

[63] The release preceded Griffin's appearances in the following two weeks on "Junya pt 2" from Kanye West's Donda and "Get Along Better" from Drake's Certified Lover Boy.

[65] The event failed to materialize, although their debut collaborative single under the recording outfit, "Vultures" (featuring Bump J) was released on November 22, 2023.

[68][69] On February 7, the first single off Tycoon, titled "Wheels Fall Off", was first teased with a behind the scenes music video shooting in Los Angeles, California, where fellow rappers Kanye West and the Game were present,[70] it was later released through the Yeezy website, with two different versions, labeled "WFO - 01" and "WFO - 02", and subsequently through streaming platforms, the song features West who also produced it, along with Kobe "BbyKobe" Hood.

[77][78] On December 10, 2018, it was revealed that Griffin was facing up to 15 years in jail in relation to cocaine and marijuana possession charges.

[81] In 2020, Griffin formally endorsed the presidential campaign of fellow rapper and frequent collaborator Kanye West.