Tygh Valley is a census-designated place (CDP) and unincorporated community in Wasco County, Oregon, United States.

Named for the Tygh (Taih, Tyigh) or "Upper Deschutes" Tenino people, Tygh Valley is considered by some to be the beginning of the Barlow Road because many wagon trains crossed the Deschutes River at Sherars Bridge and proceeded west bypassing The Dalles.

However, the National Park Service treats the first tollgate site at Gate Creek on the White River as the beginning of the Barlow Road.

[5] According to the United States Census Bureau, the CDP has a total area of 3.8 square miles (9.8 km2), all of it land.

The racial makeup of the CDP was 95.09% White, 1.34% Native American, 2.23% Asian, and 1.34% from two or more races.