J. Thornhill acquired the first tract of land for the settlement on September 20, 1816, after Native Americans were pushed out of the area.

The store and post office served as the social center of the community for over a half century.

Cullen Conerly sold his mercantile interest to his brother-in-law Benjamin Lampton.

Luter's Supply, established in 1944, is a retail center for tubs, showers, and whirlpools.

In interesting story about Tylertown and Walthall County was related in Maury Klein's book "A Call to Arms" (Bloomsbury Press, Paperback edition, 2015).

Production was lagging and crops were rotting in the fields for lack of crop pickers - farm laborers either marched off to war or to factories where wages were far superior to those earned picking cotton - and the need for more of everything was needed.

To celebrate, they decided to hold a "Food for Freedom Thanksgiving" early in October in Tylertown (population 1,100) the county seat and only post office".

According to Klein, the farming crowd came together in Tylertown and came bearing 5,000 fried chickens, 350 turkeys and enough food to feed a small army.

Claude Wickard, head of the Food Requirements Committee, appeared in Tylertown that day and extolled the virtues of the small farmer and told them that their endeavors were the "only road that leads to victory".

As of the 2020 United States census, there were 1,515 people, 618 households, and 382 families residing in the town.