The series is written by Christopher Yost with artwork by a rotating team of artists including David Lopez, Paolo Rivera, and Marco Checchetto.

A direct successor to Avenging Spider-Man and a spiritual successor to Marvel Team-Up, whose name it plays on, the series is an expansion of the Superior Spider-Man brand by Marvel Entertainment,[3] and is notable for featuring (in continuing the storyline of Avenging Spider-Man) the first appearance of the character concept of a (then-unnamed) giant spider who turned into a young girl before being taken in by the X-Men (who in January 2023 returns as Gwen Warren / Spider-Girl, the cloned daughter of Scott Summers and the Spider-Queen).

In the latest "Avenging" issues, we've seen that he has a fairly contentious relationship with most of the heroes he's encountered.

I think in issue #1, he teams up with pretty much the entire Marvel Universe".

Axel Alonso, Marvel's Editor-In-Chief, added "All I can say is, they had me at the title.