U.S. Route 90 (US 90) is a major east–west highway in the U.S. state of Texas with large portions of it running concurrently with I-10.

I-10 in Van Horn, travels through San Antonio and Houston, and continues on into the state of Louisiana.

Multiple stack interchanges are under construction to gain access in and out of the freeway along the intersections at Loop 1604 and I-410.

Further, the highway has a major junction with TX-151 as it continues eastward towards the city's inner Westside until its interchange with I-10 and I-35 at the southwest corner of Downtown.

US 90 once again duplexes with I-10 east of Columbus briefly separating near Brookshire and continue overlapping from Katy all the way to Houston.

As of December 2012, only the feeder roads have been constructed, with space reserved in the median for future freeway mainlanes.