It approaches Athens from the south where it joins SR 10 Loop, a mostly interstate-grade bypass that rings Athens-Clarke County.

US 129 enters Tennessee to the west of Great Smoky Mountains National Park and rides along Chilhowee Lake for a short distance before turning due north.

[1][2] On weekends, through spring to the fall months, visitors are likely to see numerous riders and drivers on this stretch of the highway to experience the thrill and scenery.

[3] U.S. 129 is mentioned in the popular country song Bottoms Up by Brantley Gilbert: "I see you and me riding like Bonnie and Clyde, Goin 95 burning down 129."

With the rise of the internet and telecommunications, the Tennessee section of the route has become popularized by its motoring enthusiasts who share their experiences through social messaging boards and media outlets.

This small stretch of around 11 miles starting at Deals Gap just before the Tennessee state line in North Carolina, has been nicknamed Tail Of The Dragon.