U.S. Route 76 (US 76) is an east–west U.S. highway in the Southeastern United States that travels for 548 miles (882 km).

US-76 travels concurrent with US-41 for its entire length in Tennessee, about 8.9 miles (14.3 km).

[2] US 76 passes through Catoosa, Whitfield, Murray, Gilmer, Fannin, Union, Towns, and Rabun counties.

US 76 enters South Carolina across the Chattooga River, then continues southeast toward Westminster.

From Clemson, the road heads southeast toward Anderson, intersecting Interstate 85 (I-85), then east toward the small towns of Belton and Honea Path.

US 76 provides local access to the communities of Laurens, Clinton, Newberry, Prosperity, Chapin, and the other smaller towns in the area.

It then continues east out of Florence to the small towns of Marion and Mullins, then into North Carolina.

The highway passes through Fair Bluff and becomes concurrent with US 74 from Chadbourn to Wilmington.

It crosses the Cape Fear Memorial Bridge into Wilmington and continues to Wrightsville Beach via Oleander Drive to the route's eastern terminus.

In Morganton, the stretch is joined briefly by SR 60, and, in Blairsville, a small portion of the route is unofficially part of US 19/US 129.

This old alignment from Blairsville to Blue Ridge is approximately 37 miles (60 km) long and has some of Georgia's most scenic views along its eastern end.

Significant curve realignments also occurred along the previously serpentine section from Hiawassee to Clayton from 1988 to 2005.

The original US 76 followed the current alignment of the road from the South Carolina state line to Chadbourn.