U.S. Route 129 (US 129) is a north–south United States highway that travels 63.5 miles (102.2 km) through the westernmost part of North Carolina.

At Red Marble Gap is the community of Topton, which straddles closely to Cherokee, Macon and Graham counties; here US 129 splits from US 19/US 74 as it continues into the Nantahala Gorge towards Bryson City.

NC 143 shares a short concurrency with US 129 while in Robbinsville, here is where motorcycle and sports car enthusiasts begin to appear as they connect here from the Cherohala Skyway and heads towards the Tail of the Dragon at Deals Gap.

Corridor K connects Interstate 75 (I-75) in Cleveland, Tennessee with US 23 in Dillsboro, North Carolina, overlapping 29.5 miles (47.5 km) of US 129.

ADHS provides additional funds, as authorized by the U.S. Congress, which have enabled US 129 to benefit from the successive improvements along its routing through the corridor.