Pennsylvania Avenue continues southeast from the intersection and would have connected US 140 with US 40, which then followed Franklin Street through downtown Baltimore.

US 140 headed northeast on Pennsylvania Avenue three blocks to Fulton Street, where the U.S. Highway joined Reisterstown Road at its southern end.

In the center of Pikesville, the U.S. Highway met Old Court Road at staggered intersections, neither of which were the modern course of the crossroad.

US 140's course out of Reisterstown featured sharper corners than MD 140's modern course; the U.S. Highway used Amy Brent Way through the I-795–MD 140 interchange and the paralleling road east of the Woodfield Court intersection.

Shortly before the highway entered the town of Westminster, it met the northern end of MD 683 (Poole Road).

There, the highways had in rapid succession an intersection with MD 31 (Railroad Avenue), which headed toward Manchester; a grade crossing of the Western Maryland Railway (now Maryland Midland Railway); and an intersection with the northern end of MD 27 (Liberty Street).

US 15 headed south on Steinwehr Avenue and north along Baltimore Street toward the central square of Gettysburg, where the U.S. Highway intersected US 30.

[4] The American Association of State Highway and Transportation Officials approved the removal of the US 140 designation on October 28, 1977.