U.S. Route 183 (US-183) is a part of the U.S. Highway System that runs from US-77 in Refugio, Texas north to Interstate 90 (I-90) in Presho, South Dakota.

The highways stay paired as it turns north to pass through the Comanche County seat, Coldwater.

US-56 continues northeast toward Larned, and US-183 straightens out to pass through largely unpopulated areas in Edwards County.

US-183 runs through town for three miles (5 km) before crossing Interstate 70, which is heavily traveled in Hays with traffic between Denver and Kansas City.

[3] North of Hays, the highway has been resurfaced and realigned for 23 miles (37 km) to Plainville, one of two towns in Rooks County US-183 serves.

The highways split in downtown Phillipsburg, and US-183 has one last junction with K-383 before exiting the state south of Alma, Nebraska.