U.S. Route 219 (US 219) is a part of the U.S. Highway System that runs from Rich Creek, Virginia, to West Seneca, New York.

US 219 enters Maryland in the southwest corner of Garrett County just to the west of Backbone Mountain.

After crossing the Youghiogheny River, US 219 meets US 50 (George Washington Highway) at an intersection with a two-way stop in the hamlet of Redhouse.

The highway turns northwest to intersect Ben Dewitt Road, a shortcut between US 219 and US 50 at the state line to the west, then resumes its northeasterly course heading toward Gortner, where the highway crosses Cherry Creek and Ambrose Run.

US 219 veers north and crosses the Little Youghiogheny River and CSX's Mountain Subdivision before entering the town of Oakland and meeting the west end of MD 135 (Maryland Highway).

[1][3] US 219 passes along the eastern edge of Mount Nebo Wildlife Management Area and crosses Hoop Pole Hill.

US 219 descends from Hoop Pole Ridge and reaches the southwestern shore of Deep Creek Lake in the hamlet of Thayerville.

After the highway crosses the latter road and Bear Creek, it begins the ascent to Keyser's Ridge, with the northbound direction gaining a climbing lane.

After passing Accident Garage Road, Northern Garrett High School, and a scenic overlook, the highway curves to the east and then back north as it approaches the summit.

Shortly after the descent from the summit, US 219 meets I-68 (National Freeway) and US 40 at Exit 14 of I-68 at Keyser's Ridge.

The highway passes over US 40 Alternate (National Pike) east of the hamlet of High Point before the freeway ends upon meeting the northern terminus of US 219 Bus.

From here, the route follows two-lane undivided Chestnut Ridge Road and crosses the Pennsylvania state line, where US 219 continues north toward Meyersdale.

Finally, the section from Accident to Keyser's Ridge, which bypassed the crooked road around Bear Creek, was completed in 1915.

The new road, constructed from Oakland to Gortner in 1915 and 1916, met the road to Mountain Lake Park, now Oakland Drive, next to Southern Garrett High School, then followed Oak Street west into the county seat.

A groundbreaking ceremony for the realignment of US 219 between I-68 and Old Salisbury Road was held on October 13, 2018, with Governor Larry Hogan in attendance.

U.S. Route 219 Business is a business route located east of Grantsville on Chestnut Ridge that runs 1.12 mi (1.80 km) from a dumbbell interchange with I-68/US 40 and US 219 north to an intersection with US 219, following Chestnut Ridge Road.