It then continues southeast for about 30 miles (48 km) to Leadville, where it turns south and goes to Buena Vista where it becomes concurrent with US 285.

It continues with US 285 through Trout Creek Pass to the small community of Antero Junction.

From there, it passes through Crystola, Green Mountain Falls, and Cascade.

From Colorado Springs, it continues northeast through several towns such as Falcon, Peyton, Calhan, Ramah, Simla, and Matheson.

It continues east (parallel to I-70) to Burlington where it joins I-70 to the Kansas state line.