At 1 mile, there is an intersection with Spur 147 which runs across the north side of the city to connect with Broadway and then US 69.

The SH 155 concurrency ends at 8 miles, near the University of Texas Health Science Center at Tyler.

Trucks are required to use Loop 485, a bypass around the east side of town, if they are following US 271 through the area or if they want to turn onto US 80.

Then the highway crosses Big Cypress Creek just below the dam that forms Lake Bob Sandlin.

Beyond IH 30 are the small towns of Talco, Bogata (junction with SH 37), Deport, and Pattonville.

The ODOT roadside park at the west end of the concurrency is the only one on the entire route of US 271 in Oklahoma.

There are weight limits of 15 tons (depending on vehicle length) posted between SH 144 and Clayton.

From Clayton, US 271 takes on an easterly trajectory, passing Tuskahoma and Albion, before turning northward prior to Talihina.

From Talihina eastward eight miles, US 271 runs concurrently with SH 1 until the beginning of the Talimena Scenic Drive.

US 271 was then re-routed through Talihina and Hugo, Oklahoma, as well as Paris and Tyler, Texas, towards Beaumont near the Gulf of Mexico.

It has since been realigned twice: once beginning at U.S. 71 and Y Street then crossing into Oklahoma at Arkoma, the second time to its current terminus in southern Fort Smith.