Its southern terminus is 5 miles (8.0 km) west of Coushatta, Louisiana at an intersection with Interstate 49.

The route runs north to intersect AR 160 in Taylor and winds east to Magnolia.

US 371 continues west to meet AR 98 in Waldo, before heading north to enter Nevada County.

The route passes through Nashville, again meeting US 278, and runs west through rural land and into Sevier County.

[1] Upon receiving approval, the route was officially commissioned in Arkansas as Highway 371 on 24 August 1994.