Today, US 29 and SR 15 serve primarily to connect numerous smaller towns and cities in the southwest, south-central, and eastern parts of Alabama.

Highways include US 31 from Flomaton to Brewton, US 84 in Andalusia, US 331 from Brantley to Luverne, US 82 in Union Springs, US 80 from Tuskegee to Alliance, and US 280 between exits 58 and 62 along I-85 in Opelika.

US 29 enters downtown Flomaton in a concurrency with SR 113 from a bridge over a large railroad yard north of Century, Florida.

Descending from that bridge over both the railroad yard and Ringgold Drive, the route is named Sidney E. Manning Boulevard and has its first intersection with Church Street.

The road briefly runs straight north for one block between College and Poplar streets and then turns back to the northwest.

Sidney E. Manning Boulevard ends at US 31, and US 29/SR 113 makes a right turn joining those routes in a concurrency, crossing a bridge over Big Escambia Creek.

After the bridge over Burnt Corn Creek, a truck detour veers off to the left onto Persimmon Street because the main road flanks too closely to a former Louisville and Nashville Railroad line, entering the Brewton Historic Commercial District.

The road crosses the Buddy Mitchell Bridge over Murder Creek into East Brewton, and Mildred Street becomes Forest Avenue.

Along the way, it passes through the communities of Rome and then Pleasant Home and, after curving more toward the north and leaving the forest, serves as the northern terminus of SR 137.

US 29/SR 15 turns left onto Three Notch Road, while US 84/SR 12 crosses the same railroad line it encountered northeast of the beginning of the concurrency, and runs east through Opp, Elba, and Dothan and toward coastal Georgia.

Maintaining relatively the same trajectory while the coastline of the lake moves away from the road, US 29/SR 15 enters Crenshaw County where it becomes Andalusia Highway and passes through Searight.

The road enters the town of Brantley just west of the intersection with Spring Hill Road and the name changes to West Emmett Avenue, which runs practically to the east until further downtown where it turns left onto an intersection with US 331 and unsigned SR 9 while East Emmett Avenue continues as a local city street.

Beginning near a cold-storage facility, the road runs along the west side of the same railroad line it had encountered in downtown Troy.

After passing through some of the wetlands surrounding Richland Creek, it serves as the northern terminus of SR 130 north of Monticello, and then the route curves to the northeast.

After the county line it passes through communities such as Tanyard, where it intersects CR 53 before curving more toward the north as it runs along bridges over Mill and Double creeks, then Perote, where it intersects CR 8, then makes a reverse curve as it climbs a slight hill before running straight north.

The concurrency does not end as US 29/US 82/SR 6/SR 15 makes a left turn onto Martin Luther King Boulevard North, terminating US 29 Truck.

Shortly afterward, it runs through Fort Davis which has a one block concurrency with CR 2, due to a culvert over a tributary of Dobbs Creek.

At the intersection of Saint Mark's Road, it makes a curve to the northeast and further north passes through communities such as Cotton Valley and later Davisville where it has another concurrency, this time with CR 47.

In Tuskegee, US 29 becomes Union Springs Road in front of the George Washington Carver Elementary School and makes a sharp curve to the west-northwest as it approaches CR 10, where it turns into South Main Street.

They briefly leave the forest but then reenter it together until they split at an interchange southwest of Alliance, which is also the eastern terminus of SR 186.

At exit 64, US 29 leaves I-85 and joins West Point Parkway, but the road runs in close proximity to I-85 from the Auburn area to near Winston-Salem, North Carolina.

North of this border, it starts to make a slight curve to the northeast, where it encounters a 354-foot (108 m) multiplex with CR 388,[3] the western end of which leads to I-85 at exit 70.

The route, trail, and bridge are part of the Langdale Historic District and so are the former Landgale Cotton Mill, the Sears Memorial Auditorium, and various schools.

In Lanett, the road runs over a bridge over a former Western Railway of Alabama (WRA) line and then serves as the eastern terminus of SR 50, the last state highway to intersect with US 29.

The last intersection in Alabama is with North Seventh Avenue, a local street completely dominated by a car and truck dealership.

US 29 enters the state of Georgia which runs northwest to southeast and the city of West Point, thus bringing SR 15 to an end.