WYO 215 begins at I-80 BL/US 30 (Parson Street), just north of Exit 401 on Interstate 80/US 30 in southwestern Pine Bluffs.

(I-80 BL/US 30 heads south toward Interstate 80 and north, then east, toward Nebraska, but I-80 BL no longer continues into that state.)

From its southern terminus WYO 215 heads very briefly west on a viaduct over Old U.S. 30 and four sets of railway tracks as it turns north to run just inside the western edge of Pine Bluffs.

After connecting with the western end of North Main Street, crossing over Lodgepole Creek, and connecting with the eastern end of County Road 213, WYO 215 leaves Pine Bluffs and continues north through rural agricultural area for the greater part of its course.

(North of Pine Bluffs, the county roads are spaced 1 mile (1.6 km) apart, in sequential order.