Wyoming Highway 225 (WYO 225) is a 11.21-mile-long (18.04 km) state highway, named Otto Road, located in southwestern Laramie County west of Cheyenne, in the U.S. state of Wyoming.

Wyoming Highway 225 begins its western end at exit 348 of Interstate 80/US 30 east of Granite Canon.

WYO 225 heads east toward Cheyenne, roughly paralleling I-80/US 30 to the south, as it was the former routing of the latter.

[1][2] Reaching the western outskirts of Cheyenne, the southern terminus of Wyoming Highway 222 (Roundtop Road) is intersected, which heads north to F.E.

Warren AFB and also provides access to exit 357 of the interstate.