runs 10.80 miles (17.38 km) through Baton Rouge, the capital city of Louisiana.

[2] The route is entirely concurrent with US 190 Bus., forming a loop off of mainline US 61/US 190 (Airline Highway) through the downtown area.

The business route was first put into effect in 1954 and assumed its current alignment in 1960.

ran 10.73 miles (17.27 km) through St. Francisville, a town in West Feliciana Parish, Louisiana.

Like several other special routes in Louisiana, the designation was unofficial, not recognized by AASHTO or printed on the official state highway maps.

US 61 BUS in Natchez, MS uses part of US 425/US 84, then turns onto Homochitto Street.

in Bowling Green, MO is a four mile long business route of US 61.

As it travels into Keokuk, it follows US 136 and the two routes run parallel to the Mississippi River just to the south.

At the southern end of downtown Keokuk, US 136 turns to the southeast to travel across the Keokuk–Hamilton Bridge to Illinois.

Iowa 2 splits away to cross the river near downtown and the route turns north and heads out of town.

US 61 Business heads north through Muscatine's industrial area and into the downtown riverfront.

is overlapped by US 67, which joins from the south at the Centennial Bridge and parts to the north when US 61 Bus.

Just south of Kimberly Road, which carries US 6, the southbound lanes of US 61 Bus.

Although not designated until 1998, Main Street had essentially served as a "Business 61" since at least the mid-1970s, when U.S. 61 was moved to a two-lane bypass around the south and west parts of the city.

ran 6.7 miles (10.8 km) through Baton Rouge, the capital city of Louisiana.

[14] It followed the Airline Highway, a four-lane bypass of the downtown area constructed in 1941.