[3] After turning north, US 61/190 Business follows the Mississippi River for a short time, passing the Louisiana State Capitol to the west by one block.

US 61 takes over Scenic Highway, heading north towards Natchez while US 190 continues west towards the Huey P. Long Bridge and Opelousas.

When the US 61/190 Bypass was built around Baton Rouge, a traffic circle existed at the current cloverleaf intersection that defines the southern terminus of US 61/190 Business.

[9] As of December 2020, all Louisiana documents point to US 61/190 running on the pre-2019 alignment,[10] with the exception of internal routings which show that the portion of Florida Street between I-110 and River Road having been transferred back to the City of Baton Rouge.

[11] Additionally, the application from LaDOTD to AASHTO mentioned that existing parts of the business route would be transferred in sections over time.