US 76 begins at an intersection with US 41/US 72/SR 17 (Broad Street) in downtown Chattanooga.

It goes east, running concurrently with US 41/SR 17 (as Main Street) through some industrial areas, where SR 8 (Market Street) joins the concurrency, before entering suburbs and coming to an intersection with South Willow Street, where SR 17 splits off and goes north.

US 41/US 76/SR 8 then comes to an intersection with US 11/US 64/SR 2 (Dodds Avenue), where they turn south to run concurrently with those three highways for a short distance before US 11/US 64/SR 2 turns east onto East 23rd Avenue while US 41/US 76/SR 8 turns southeast onto Westside Drive and an interchange with I-24 (exit 181A).

It travels through the city and then meets an interchange with I-75 (exit 1) before entering Georgia, where SR 8 ends and US 41/US 76 runs concurrently with SR 3, which begins here.

The entire route of US 76 in Tennessee is in Hamilton County and is concurrent with US 41 and SR 8.