It would have been a large-profile (Großprofil) metro line running from Falkenberg, in the northeastern part of the city, to Alexanderplatz, and down to Steglitz before terminating at Drakestraße in Lichterfelde.

Prior to die Wende, the U10 line was in some other proposals intended to run from Drakestraße to the Kulturforum and then via the Brandenburg Gate/Reichstag to Lehrter Stadtbahnhof (now Berlin Hauptbahnhof), and from there continue along Lehrter Straße to the vicinity of the Schering AG headquarters in Wedding.

Around 1993–96, after reunification, the original 1950s plans for the U10 were discarded in favour of a provisional line U3/U35 (not to be confused with the current U3).

The aforementioned revised U10 alignment (shown in the attached map as a dark turquoise dashed line from Weißensee to Adenauerplatz) nevertheless remains legally safeguarded as part of Berlin's Land-use plan since 1994, which means that construction along the proposed route must accommodate the eventuality of such a line.

In 2023, Manja Schreiner [de], a CDU politician serving as Berlin's Transport Minister, proposed a new U10 alignment running from Alexanderplatz to Buch via Weissensee, partly also to relieve the overcrowded M4 tram line.