UPHS Marquette is a Level II trauma center[1] and a teaching hospital, affiliated with the Michigan State University College of Human Medicine.

St. Luke's expanded steadily through the early and mid-20th century, adding pediatric services, a nursing school, and an intensive care unit.

Marquette General continued to expand the former St. Luke's campus, adding more services for the growing population of the region.

As of December 2022[update], some services remain on the old Marquette General Hospital campus, which is scheduled to be fully vacated by early 2024.

[9][10] UPHS Marquette is the center of UP Health System, a three-hospital network in the Upper Peninsula operated by Duke LifePoint.