[9] The primary structure of UQCRFS1 from cDNA analysis is composed of a 78 amino acid long N-terminal extension sequence.

[10] The UQCRFS1 gene encodes for an iron-sulfur protein, which is an essential subunit of the Ubiquinol Cytochrome c Reductase or Complex III in the mitochondrial respiratory chain.

[12] Once it is incorporated, UQCRFS1 undergoes proteolytic processing, which is essential for the correct insertion into Complex III.

Preventions of the insertion may occur due to UQCRFS1-derived fragments, leading to a loss of Complex III structure and function.

[16]This article incorporates text from the United States National Library of Medicine, which is in the public domain.