USCGC Iroquois (WHEC-43) was an Owasco-class high-endurance cutter built for World War II service with the United States Coast Guard.

Iroquois was built by Western Pipe & Steel at the company's San Pedro shipyard.

Named after Lake Iroquois (Vermont), she was commissioned as a patrol gunboat with ID number WPG-43 on 9 February 1946.

Her ID was later changed to WHEC-43 (HEC for "High Endurance Cutter" - the "W" signifies a Coast Guard vessel).

Both of her boiler burners were removed and installed on board her sister cutter, Escanaba.