USS Escambia (AO-80) was the lead ship of her subclass of the Suamico class of fleet oilers acquired by the United States Navy for use during World War II.

After a December 1943 voyage from the U.S. West Coast to Pearl Harbor with oil cargo, Escambia departed San Francisco, California, on 21 January 1944 for Majuro, arriving on 9 February.

Escambia arrived at Manus on 14 September 1944, and sailed out of this port to rendezvous at sea to fuel the carriers as they launched the air strikes preliminary to the assault on the Philippines.

The oiler returned to Ulithi on 18 April 1945, and for the remainder of the war used this as her base as she fueled the carrier task forces supporting the Okinawa invasion, and raiding and bombarding the Japanese home islands.

Escambia paid calls to Okinawa and Wakayama Wan to fuel ships at anchor there until leaving Tokyo astern, homeward bound, on 4 November 1945.