This location is approximately 4.5 kilometres (2.8 mi) north of the central business district of Kampala, the capital and largest city of Uganda.

The Institute is now a provider of cardiovascular services and the only National Referral Facility for heart diseases in Uganda.

The Institute is partnering with various stakeholders including civil society, to promote health through advocating for a healthy lifestyle.

What Uganda Heart Institute needs now is more working space and lager operational budgets to enable it fulfill its mandate.

This resurrected plans to establish a specialized cardiac unit at Mulago, began in 1958, but were killed in 1972, with the expulsion of the Ugandan Asians by dictator Idi Amin.

[1] Since 1988, the Institute has received valuable contribution from national and international donors including the Rotary Club.

The new hospital will have three operating theatres, cardiac catheterization laboratories, an Intensive Care Unit, and research facilities.

[8][9] The New Vision newspaper, reported in November 2016, that Uganda Heart Institute had acquired land measuring 2.5 acres (10,000 m2) along Owen Road in the Mulago neighborhood, where it was going to build its new headquarters.

[10] In April 2022, Dr John Omagino, the Executive director of UHI disclosed that the institute had acquired 10 acres (4.0 ha) of land in the Naguru–Nakawa Government Complex.

[13] In February 2025, the beginning of construction of the initial 250-bed hospital was flagged off by Uganda's prime minister, Robinah Nabbanja.

Two Chinese construction companies, who did not win the bid, complained to a government tribunal that adjudicates such disputes in the country.