According to the 2000 U.S. census, the metropolitan areas with the largest numbers of Ukrainian Americans are: New York City with 160,000; Philadelphia with 60,000; Chicago with 46,000; Detroit with 45,000; Los Angeles with 36,000; Cleveland with 26,000; Sacramento with 20,000;[4] and Indianapolis with 19,000.

Many Ukrainians of the newest immigration wave settled in large cities and regional centers, forming ethnic enclaves.

On September 11, 2001, 11 Ukrainian Americans perished at the World Trade Center in New York City during the acts of mass terrorism committed on that day.

All of their names were listed and commemorated by Ukrinform, the National News Agency of Ukraine, during the nineteenth anniversary of the attacks in 2020.

[14][15] In Bloomingdale (near Chicago) on September 21, 2015, Filaret, the Ukrainian Orthodox Patriarch of Kyiv and All Rus'-Ukraine, consecrated the first North American monument to the Revolution of Dignity's "Heavenly Hundred".

[17] There are a large number of Ukrainian Protestants in the Sacramento metropolitan area who have organized support to those affected by the invasion of Ukraine through their local congregations.