[1] Union Hospital was founded August 11, 1892 as the Terre Haute Sanitarium by Dr. Benjamin F. Swafford and Dr. Leo J. Weinstein.

The name was changed in 1895 to Union Home for Invalids after the two doctors donated half of their holdings to a group of citizens of various Protestant and Jewish backgrounds.

[4] Since the early 1960s, the hospital has maintained a partnership with Indiana State University, where both institutions collaborate with the School of Nursing and related programs.

[5] Beginning in the 1960s, physicians Dr. Thomas Conway and Dr. William Scully researched groundbreaking practices of infant care to develop a new neonatal program.

Soon, they asked the hospital board to train nurses at Yale University, in order to implement these practices in Terre Haute.