The first students were admitted to the University of Central Greece in September 2004, at which time only the informatics department was in operation.

The Department of Regional Economic Growth, which was founded in 2005, began its operation in the academic year 2005-2006.

The Department of Computer Science and Biomedical Informatics was housed in the former Lamia Academy, near the old municipal hospital and the public aquatics centre.

The first floor housed facilities such as lecture classes, two labs, one computer cluster, as well as administrative services and the faculty offices.

An external evaluation of all academic departments in Greek universities will be conducted by the Hellenic Quality Assurance and Accreditation Agency (HQA) in the following years.